alliThere’s an over-the-counter weight loss drug called Alli made by the huge phar­ma­ceu­ti­cal Gla­xoS­mith­Kline. You can see it on the shel­ves of most any Wal Mart or local drug store.  It’s also called Orlis­tat which is mar­ke­ted under the trade name of Xeni­cal by the phar­ma­ceu­ti­cal Roche.

It’s pro­mo­ted as safe, and it works by limi­ting the absorp­tion of fats from what you eat, which in turn redu­ces your intake of calo­ries.  (What has always tur­ned me off about Alli or Orlis­tat is that is crea­tes oily and loose stools. Bleck. )

Meds­cape just today repor­ted about an FDA war­ning: the Use of orlis­tat may dec­rease L-thy­ro­xine (T4) absorp­tion and lead to hypothy­roi­dism. Cli­ni­cians are advi­sed to admi­nis­ter levothy­ro­xine and orlis­tat at least 4 hours apart…

Oh jolly. So now we have the FDA giving a war­ning about Alli cau­sing pro­blems with “thy­ro­xine” use,  yet it’s the VERY “thy­ro­xine” use that cau­ses a cer­tain large per­cen­tage of those using Alli to need to use it in the first place. You can see that rea­lity in the ques­tions about the hypo pro­blem on the Alli forum.  i.e They are all on thyroxine!

Hit­ting my head against the wall.

P.S. Repor­ted in Endoc­rine Today and from just a month ago, and article tit­led Hypothy­roid patients requi­red inc­rea­sed levothy­ro­xine during preg­nancy.  Zom­bie Endoc­ri­no­lo­gists. Zom­bies. That’s like having an article tit­led Sick patients need more blood-letting. i.e LEVOTHYROXINE SUCKS AND SHOULD BE IN THE PAST just as much as blood-letting.  WAKE UP ENDOCRINOLOGISTS!! WAKE UP!!

*Check out patient res­ponse to the newly for­mu­la­ted Armour below, and add your own comments.


  • Want to keep track of these “fringe web­site” blog posts? ;-) Curious what’s on Janie’s mind? Use the noti­fi­ca­tion on the lower left of the links, called a News­let­ter, or an RSS Feed.
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  • Check out the patient-to-patient book with even more detail (and which doc­tors seem to res­pect more than websites).
  • Need to unders­tand all your best options for thy­roid treat­ment? Go here.
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4 Responses to “A un-brilliant double whammy by the FDA concerning a weight loss medication”

  1. Dwayne said:

    May 01, 09 at 6:30 am

    They will never wake up. I work in a Pri­mary Care net­work and I have to tell you– it’s pathe­tic– the whole thing. I can’t believe how unde­du­ca­ted these doc­tors are. It’s extre­mely anno­ying and frus­tra­ting. Thank god I go to a holis­tic MD as she knows what she is doing far supe­rior to these wanna be doctors!

  2. Violet Lewis said:

    May 04, 09 at 2:07 pm

    I was given your web site last year. After I read it all many times, clic­ked on all links, I sat down and cried. I am 66 and when I was a tee­na­ger, I remem­ber taking thy­roid. I was thin. I had asthma, and just used every ounce of food, I guess. When I was 21, I had my first child and went from 100 pounds to 150. I am 5ft tall. I was 24 and a Doc­tor told me one thy­roid gland was twice the size of the other. So he used the radia­tion treat­ment to remove it.

    Fast for­ward to 2 years ago. I have had to fight weight for all those years. It was not till I could not walk and so exhaus­ted i nearly fell to the ground. My heart Doc­tor put me in the hos­pi­tal for 48 hours and took every test he could find. At the end he asked me if I ever had a thy­roid pro­blem. I told him yes and explai­ned what happened.

    Now I have a dia­be­tic Doc­tor for 5 years. I HAD TOLD HER ABOUT MY THYROID SURGERY. She took the usual test and my TSH was fine. But I still felt lousy. It was not till my heart Doc­tor put me on thy­roid meds did she say anything ( and she was pis­sed he found it and she did not. ) I was pis­sed too.

    I finely found a Doc­tor way out from me to take more tests and found my T3 was low. She gave me cyto­mel 25mg. I am also on levoth­ro­xine 50mg. I know it is not the best. My heart Doc­tor has me on lots of mine­rals and sup­ple­ments with only a few Prx. But I still can barely make it through the day.

    I have found a Endoc­ri­no­lo­gist in San Anto­nio. I have had to push and needle to get the tests I want. Why do they fight it?? Doc, it is my body and my $$$ I now weigh 245. It makes me sick.

  3. Amy H said:

    May 08, 09 at 7:21 am

    I just HAVE to put in a war­ning here about Alli and other punish­ment we give our­sel­ves for being over­weight after thy­roid issues. Our bodies needs fat and cho­les­te­rol to make hor­mo­nes in the first place, even more so than healthy peo­ple, since we have to rege­ne­rate a lot after all the damage from not having enough thy­roid hor­mo­nes for howe­ver many years it took for our doc­tors to figure it out. I know this is a bit off topic of the post but your body does need fat, pro­tein, and car­bohy­drate together, tai­lo­red to your phy­si­cal acti­vity and other needs.

    It is very dan­ge­rous to block your body’s absorb­tion, of fats, or anything else in that mat­ter, and expect to have enough nutrients and buil­ding blocks to keep your meta­bo­lism run­ning and the manu­fac­ture of all types of hor­mo­nes. Fat has NUTRIENTS that your body needs!!

    If you already have a poorly func­tio­ning meta­bo­lism from being under­trea­ted for thy­roid, you’ll find your­self in an even worse situa­tion when you try any extreme diet tech­ni­que. The only way to lose weight safely and not hurt your­self is to get your meta­bo­lism ope­ra­ting well again with pro­per thy­roid and adre­nal sup­port, get plenty of rest, time with friends and loved ones, avoi­dance of stress if pos­si­ble, low-impact excer­size from something you enjoy doing (like wal­king in the park or pla­ying soc­cer with your kids in the yard, etc), eating sen­sibly from ALL food groups (that does not inc­lude brow­nies and mar­ge­rine, chef­bo­yar­dee ravio­lis from a can, mic­ro­wave din­ners, things filled with MSG and other che­mi­cals), and NOT, I repeat NOT, seve­rely res­tric­ting food intake OR any one part of fat, pro­tein, carbohydrate.

    I apo­lo­gise for my rant but my mother is a nutri­tio­nist and I am a thyroid/adrenal patient too! I don’t want to see anyone suf­fer even more. Believe me, I’m in the ‘got a bit of extra weight I’d sure like to lose with crash die­ting’ boat too, but I’m just not giving in. I’m let­ting my meta­bo­lism heal after years of being sick and I’m just gonna have to be patient. So your’re going to have to love me and your­self a little fat­ter for a while and who cares because you’ve got hea­ling to do!!!

  4. Andrew - Weight Loss Melbourne said:

    May 15, 09 at 12:31 am

    I must agree with Dwayne. In my work­place we have alot of peo­ple who come to us after they have been through the une­du­ca­ted mass of grinder-type gene­ral practitioners.

    To just what end will peo­ple be led in order to create a higher pro­fit margin.


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